Aim of the present study is to evaluate the protective effect of morin hydrate on behavioral and biochemical alterations in animal model of huntingtons disease. Antioxidant properties of flavonoid are very well known. Many flavonoids have been studied for their effect in neurodegenerative diseases. 3-Nitropropionic acid (3-NP) is a well known experimental animal model of huntington’s disease (HD). Intraperitonial administration of 3-nitropropionic acid (10 mg/kg) treatment for 14 days in wistar rats successfully induced huntingtons disease (HD). Pretreatment with morin hydrate (50 mg/kg/b.wt and 80 mg/kg/b.wt) significantly modified many behavioral and biochemical alterations in the animal model. Behavioral alterations such as locomotar activity, muscle grip strength, memory dysfunction were assessed by using open field apparatus, rotarod apparatus, elevated plus maze respectively. Oxidative defense and mitochondrial enzyme activities were also estimated in the striatum. Results of this study showed that morin hydrate significantly attenuates the behavioral and biochemical alterations compared to the huntingtons control group. Thus the protective effect of morin hydrate against 3 nitropropionic acid induced animal model of huntingtons disease has been justified.
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